别 名Antagonist of beta-catenin Dapper homolog 3; Arginine rich region 1; Arginine rich region 1 protein; Arginine-rich region 1 protein; Dact3 antibody; DACT3_HUMAN; Dapper antagonist of beta catenin 3; Dapper antagonist of beta catenin homolog 3 (Xenopus laevis); Dapper homolog 3; Dapper3; Dpr3 antibodyRRR1; RRR1; Thymus expressed gene 3 like.
说 明 书100ul
交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep,
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
Anti-DACT3/FITC抗体性 状Lyophilized or Liquid
免 疫 原KLH conjugated synthetic peptide derived from human DACT3
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Dapper3 is a 629 amino acid protein and mammalian homolog of the Xenopus laevis protein dapper. As a member of the dapper family, Dapper3 plays a role in postnatal brain development and contains a C-terminal PDZ-binding motif that facilitates interaction with the PDZ domains of DSH (Dishevelled) family proteins. As the predominant dapper family member found in ***** brain, Dapper 3 localizes to hippocampus, Purkinje cell layer and every layer of the dorsal forebrain and cerebral cortex and is also found in the developing murine central nervous system. Dapper3 is also expressed in uterus, ventral somites, branchial arch mesenchyme, aortic sac, aortic arches, limb bud mesenchyme and craniofacical mesenchyme. Mapping to human chromosome 19q13.32, Dapper3 has been identified as a negative regulator of Wnt/beta-catenin signaling in colorectal cancer.
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.
Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.
Belongs to the dapper family.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.