最新大奖娱乐官网下载:钠通道亚基β4抗体 SCN4B

产品价格: < 面议
产品型号: SCN4B
 牌:单克隆抗体/多克隆抗体
公司名称:上海信裕生物技术有限公司
  地:上海松江
发布时间:2018-08-10
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钠通道亚基β4抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和免疫抗体。钠通道亚基β4抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。

产品详细信息

钠通道亚基β4抗体

规格:1mg/1ml

英文名: SCN4B

别名: SCN4B_MOUSE; SCN4B_HUMAN; Sodium channel subunit beta-4.

分子量: 22kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

免疫原:KLH conjugated synthetic peptide derived from human SCN4B

交叉反应:Mouse, Rat,

细胞定位:细胞膜

钠通道亚基β4抗体产品介绍:background: The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed at a high level in dorsal root ganglia, at a钠通道亚基β4抗体 lower level in brain, spinal cord, skeletal muscle and heart. Post-translational modifications: Contains a number of interchain disulfide bonds with SCN2A. DISEASE: Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Similarity: Belongs to the钠通道亚基β4抗体 sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Gene ID: 399548 Database links: Entrez Gene: 6330 Human Entrez Gene: 399548 Mouse SwissProt: Q8IWT1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

钠通道亚基β4抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:心血管  神经生物学  信号转导  通道蛋白  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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